The application of Wyckoff and VSA analysis is less consistent...

The application of Wyckoff and VSA analysis is less consistent in small and micro cap stocks for sure, mainly because unexpected supply events can arrive at any time, and spoil the analysis somewhat. And yes taking a longer timeframe view does help in both the analysis and the trading at this end of the market.
That is not to say you cannot trade spec's in shorter timeframes (the volatility can be great), it is just that the dangers are increased (compared to larger, more liquid stocks), so you might need to become more nimble when trading at this end of the market.

Whereas higher liquidity, or larger market cap stocks offer more consistancy to the analysis, and unexpected supply is much less common, which therefore allows for more confidence when trading all timeframes, and especially shorter timeframes (when compared to small and micro caps) in particular.

cheers