Terumo and Propofol Injectable, page-14

Complex, toxic or allergenic excipients
• Unstable formulation needing lyophilisation
• Drugs too unstable to be an injectable
• Need for ‘Cold chain’ to maintain stability
• Reconstitution of lyophilised powders
• Allergenic or toxic excipients
• Post reconstitution stability, single use only
• Incompatibility with injectable formulations

TPM
• A safer and more natural excipient
• Improve stability reducing need to lyophilise
• Allows previously unsuitable drugs to be injectable
• Reduce ‘cold chain’ by improving RT* stability
• Speed up reconstitution of lyophilised drugs
• Replace problem excipients
• Increase stability of reconstituted drugs –
potentially allowing multi-use products​

• Enable injectable formulation