RESEARCH ARTICLE...

RESEARCH ARTICLE
https://onlinelibrary.wiley.com/doi/full/10.1002/jcla.22576
Clinical value of jointly detection pleural fluid Midkine, pleural fluid adenosine deaminase, and pleural fluid carbohydrate antigen 125 in the identification of nonsmall cell lung cancer‐associated malignant pleural effusionFan Zhang  Junjun Wang  Xiaoyong Zheng  Lijuan Hu  Jie Chen

First published: 23 May 2018

https://doi.org/10.1002/jcla.22576[/BCOLOR]

Abstract
Background
Midkine (MK) level has been shown to be elevated in serum of patients with nonsmall cell lung cancer (NSCLC). However, the diagnostic value of MK in pleural effusion in NSCLC has not been well validated and established. detection of pMK + pCA125 + pADA suggested that the sensitivity, specificity, and AUC was 82.54%, 74.19% at the cutoff 0.47 and diagnostic performance was higher than others.

ConclusionJoint detection of pMK + pCA125 + pADA can be used as a good indicator for the identification of MPE of NSCLC.