Evgenii Belykh will speak at the forthcoming conference in Venice and co-authored an article last year with the follwing conclusion:
Conclusions
Intraoperative CLE using FNa provided real-time in vivo and ex vivo histological information precisely related to the site of tissue imaging and for tissue biopsy. Although FNa may not provide specific tumor labeling, the specificity and sensitivity of CLE to diagnose gliomas and meningiomas were comparable to those of frozen section, using permanent histological sections as the standard. These data suggest that in vivo and ex vivo CLE could allow the interactive identification of tumor areas, substantially improving intraoperative decisions during the resection of brain tumors and radically changing the neurosurgery-neuropathology work flow in the operating room.
Investigations to discover clinically safe and more specific fluorescent stains, labels, or probes for brain applications are required. Further development of CLE systems should address improvements in image resolution and acquisition parameters.
It also demonstrates that our friends at CZM have not been sitting on their hands:
Acknowledgments
We thank Guido Hattendorf of Carl Zeiss Surgical GmbH for expert technical assistance. We thank the Neuroscience Publications staff of Barrow Neurological Institute for assistance in preparing this manuscript.
Now for bumper sales of the CZM "Digital Biopsy Tool" and a much higher share price for OIL.
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