Rotenone / PD, page-2

This is from Wikipedia:

Rotenone works by interfering with the ​

electron transport chain​

in ​

mitochondria​

. It inhibits the transfer of electrons from iron-sulfur centers in ​

complex I​

to ​

ubiquinone​

. This interferes with ​

NADH​

during the creation of usable cellular energy (​

ATP​

).​

^[8]

Complex I is unable to pass off its electron to ​

CoQ​

, creating a back-up of electrons within the mitochondrial matrix. Cellular oxygen is reduced to the radical, creating ​

reactive oxygen species​

, which can damage ​

DNA​

and other components of the mitochondria​