thats pretty big news... we could be in a situation where we are...

First 2 Last

Share
Profile

Follow
pierre77

1,382 Posts.

54

02/02/19

12:48

Post #: 37308756
Share

Originally posted by pivalde: ↑

Brain Inj. 2019;33(3):305-312. doi: 10.1080/02699052.2018.1552988. Epub 2018 Dec 3.
Metal chaperones: a novel therapeutic strategy for brain injury?
Portbury SD¹, Sedjahtera A¹, Perrones K¹, Sgambelloni C¹, Zhang M², Crack PJ², Finkelstein DI¹, Adlard PA^1,³.
Author information

Abstract
OBJECTIVE:
This study sought to assess the potential efficacy of a novel class of metal chaperone on the outcomes in an animal model of a controlled cortical impact. This work was predicated on previous observations that this class of compound has exhibited neuroprotective potential in other models of aging and neurodegeneration.
RESEARCH DESIGN:
The study employed a controlled cortical impact traumatic brain injury in three month old mice with subsequent behavioral and cellular assessments to determine therapeutic efficacy.
METHODS:
Cognitive (Y-maze) and motor assessments (Rotarod and Open Field) were employed to determine behavioral end points. Histological-based methods were utilized to assess neuronal integrity, astrocytosis, and lesion volume.
OUTCOMES:
We demonstrate here that acute post-injury treatment with PBT2 (Prana Biotechnology) is sufficient to maintain neuronal integrity (evidenced by decreased lesion area and increased numbers of neurons; decreased astrocytosis was also present) and to normalize performance in cognitive testing (Y-maze). These effects occurred within days and were maintained for the entire duration of the study (26 days post-injury). These data support the further interrogation of the utility of metal chaperones for the treatment and/or prevention of the neuroanatomical, biochemical, and behavioral deficits that occur following brain injuries of different etiologies.

Expand

thats pretty big news... we could be in a situation where we are running 2 trials simultaneously shortly.. very interesting!!

strong buy here, especially as they will be cashed up

PBT Price at posting: 3.9¢ Sentiment: Buy Disclosure: Held
8 Upvote

0 Great analysis

Reply

Top Stories

CAF

IP anomaly thrills Cannidah with project extension hopes in QLD

PCL

HotCopper users react as Pancontinental Energy's trading halt lift reveals little

WC8

Pan Asia rebranding to 'clear confusion' after bagging $35M for Chile projects

CMB

Asian Battery Metals uncover second massive sulphide discovery at Mongolia's Oval play

GRL

To make modern missiles, you need 3D Printing. And in that gold rush, Amaero is selling shovels

MIN

MinRes's Ellison knows he screwed up – for that reason, hunt for new Chair to be sped up

ASX Market Open: Aussie market to leap on best 'Trump trade' bump since election day | November 22, 2024

BTH

Bigtincan's Board backs Investcorp offer: Why a NASDAQ listing could be game-changing

C1X

iTech inks deal with Chilean lithium giant to progress Reynolds Range

ALY

Alcidion inks deal with Vic health provider Peninsula for use of Miya Precision tech

There are more pages in this discussion • 2 more messages in this thread...

First 2 Last

Add PBT (ASX) to my watchlist

thats pretty big news... we could be in a situation where we are...

Top Stories

IP anomaly thrills Cannidah with project extension hopes in QLD

HotCopper users react as Pancontinental Energy's trading halt lift reveals little

Pan Asia rebranding to 'clear confusion' after bagging $35M for Chile projects

Asian Battery Metals uncover second massive sulphide discovery at Mongolia's Oval play

To make modern missiles, you need 3D Printing. And in that gold rush, Amaero is selling shovels

MinRes's Ellison knows he screwed up – for that reason, hunt for new Chair to be sped up

ASX Market Open: Aussie market to leap on best 'Trump trade' bump since election day | November 22, 2024

Bigtincan's Board backs Investcorp offer: Why a NASDAQ listing could be game-changing

iTech inks deal with Chilean lithium giant to progress Reynolds Range

Alcidion inks deal with Vic health provider Peninsula for use of Miya Precision tech

Featured News