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FPI think, that for now, it'll be SOC through to end of P2. ...

  1. Mer
    379 Posts.
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    FP

    I think, that for now, it'll be SOC through to end of P2.  Note, from Cisplatin side effects . . .

    • Low blood counts
      . Your white and red blood cells and platelets may temporarily decrease. This can put you at increased risk for infection, anemia, and/or bleeding. Nadir: Meaning low point, is the point in time between chemotherapy cycles in which you experience low blood counts.
      • Nadir: 18-23 days. Recovery: 39 days

    Cisplatin is given on day 56 and it looks like another 39 days until the immune system has recovered.  The LT maintenance has the first dose on day 98, just after the immune system should have dragged itself off the floor. 

    I suspect that LT dosing of the 1B and P2 patients will function as an unofficial trial without chemo.

    Didn't Leslie mention somewhere that they were looking to pivot the B-vaxx trial?  If so, could that include Her-vaxx, now that safety is good?  Wild conjecture, no idea about the rules surrounding the B-vaxx trial.

    Cheers.

 
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