Thisisalsoafreepaper.Sowhenwegetolderironwillaccumulatealsointoourhematopoieticsystemandwewillgetdiseasesrelatedtothat.Thispapertalksmostlyaboutsideeffectofbloodtransfusionsandnotaboutironaccumulationbyage,butitdoesnotmatterhowtheironaccumulatesIMO.Ithinkthatwhenwegetoldwegetthesehematopoieticdiseases(anemiaetc)moreeasilyatleastpartlybecauseofaccumulatingiron.Buttakingirontabletstheproblemgetsworse(?).I just need to add that iron overload needs to be confirmed by lab testing in any case, cardiac, hematopoietic or else. If you have real iron deficiency, more iron is needed. So diagnostics is important, overload or not needs to be known.Cells.2019Mar8;8(3).pii:E226.doi:10.3390/cells8030226.ExcessiveReactiveIronImpairsHematopoiesisbyAffectingBothImmatureHematopoieticCellsandStromalCells.
Abstract
Ironoverloadistheaccumulationofexcessironinthebodythatmayoccurasaresultofvariousgeneticdisordersorasaconsequenceofrepeatedbloodtransfusions.Thesurplusironisthenstoredintheliver,pancreas,heartandotherorgans,whichmayleadtochronicliverdiseaseorcirrhosis,diabetesandheartdisease,respectively.Inaddition,excessiveironmayimpairhematopoiesis,althoughthemechanismsofthisdeleteriouseffectisnotentirelyknown.Inthisstudy,wefoundthatferrousammoniumsulfate(FeAS),inducedgrowtharrestandapoptosisinimmaturehematopoieticcells,whichwasmediatedviareactiveoxygenspecies(ROS)activationofp38MAPKandJNKpathways.Ininvitrohematopoiesisderivedfromembryonicstemcells(EScells),FeASenhancedthedevelopmentofdysplasticerythroblastsbutinhibitedtheirterminaldifferentiation;incontrast,ithadlittleeffectonthedevelopmentofgranulocytes,megakaryocytes,andBlymphocytes.Inadditiontoitsdirectseffectsonhematopoieticcells,ironoverloadalteredtheexpressionofseveraladhesionmoleculesonstromalcellsandimpairedthecytokineproductionprofileofthesecells.Therefore,excessiveironwouldaffectwholehematopoiesisbyinflictingviciouseffectsonbothimmaturehematopoieticcellsandstromalcells.
