Iron chelation for critically ill ?, page-2

Some more support:

Sci Rep. 2018 Jul 23;8(1):11072. doi: 10.1038/s41598-018-29353-2.
High Serum Iron level is Associated with Increased Mortality in Patients with Sepsis.

Lan P¹, Pan KH¹, Wang SJ², Shi QC³, Yu YX², Fu Y⁴, Chen Y³, Jiang Y³, Hua XT³, Zhou JC⁵, Yu YS³.
Author information


Abstract

Iron is an essential nutrient for bacterial survival and thus higher iron levels may precipitate bacterial infections. We investigated the association between the serum iron level and prognosis in patients with sepsis by using the single-centre Medical Information Mart for Intensive Care III (MIMIC-III) database. Sepsis patients with iron parameters measured on ICU admission were included and stratified according to quartiles of serum iron levels. A total of 1,891 patients diagnosed with sepsis according to the Sepsis-3 criteria were included in this study, 324 of whom were septic shock. After adjusting for confounding variables, higher iron quartile was associated with an increase in 90-day mortality in the Cox regression analysis. Moreover, a stepwise increase in the risk of 90-day mortality was observed as the quartiles of serum iron levels increased in the patients with sepsis. In conclusion, higher serum iron levels were independently associated with increased 90-day mortality in this large cohort of patients with sepsis.​