Unfortunately this is only a short abstract but some of us may have possibilities to read it. PBT434 fights against cell death.
Mol Neurobiol. 2018 Nov 8. doi: 10.1007/s12035-018-1403-3. [Epub ahead of print]Ferroptosis and Its Role in Diverse Brain Diseases.
Weiland A1, Wang Y2, Wu W2, Lan X1, Han X1, Li Q3,4, Wang J5.
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Abstract
Ferroptosis is a recently identified, iron-regulated, non-apoptotic form of cell death. It is characterized by cellular accumulation of lipid reactive oxygen species that ultimately leads to oxidative stress and cell death. Although first identified in cancer cells, ferroptosis has been shown to have significant implications in several neurologic diseases, such as ischemic and hemorrhagic stroke, Alzheimer's disease, and Parkinson's disease. This review summarizes current research on ferroptosis, its underlying mechanisms, and its role in the progression of different neurologic diseases. Understanding the role of ferroptosis could provide valuable information regarding treatment and prevention of these devastating diseases.
Ferroptosis in brain diseases
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