Also tongue in cheek reply chucke. I am thinking of buying back...

Also tongue in cheek reply chucke. I am thinking of buying back in as soon as I work out why the price is still falling. Conventional wisdom has a company with no approved drugs running a clinical trial, as worth more than the same company running no trial. Prana may be intending to run the P2 in the USA. I would like to know the answer to that. The way the FDA treated Prana over PBT2 is a long way from passing the smell test IMO. To refused them even the ability to run a clinical trial, after such a stellar human safety record, and when a drug(DFP) with stronger attraction to both copper and zinc is already FDA approved for human use, is suspect IMO. I would like some detail on the LT toxicity testing yet to be completed, like at least start date and projected finish date at least. Investors and not just insiders should know at least that much. That test, with PBT2, crashed what was left of the SP to its current sorry state, so I think it is reasonable for shareholders to be updated on dose levels and how that test is progressing for PBT434. 

Think about it, if not for that LT PBT2 dog Tox result, Prana could have been in (or completed)a phase 3 right now for HD early stage patients with primary endpoints of executive function(TMTB) and brain atrophy, where PBT2 has given evidence of efficacy in multiple trials.  My investor horizon is waiting for some hard facts, but it is hard to resist these bargain basement prices.

I have taken entro-vioform(clioquinol) myself on several occasions when working around the middle east in the 70's and don't recall any episodes of blindness or paralysis, although same can't be said for some of the local brews. 

There is a lot of info gleaned from LT tox studies. For instance the DFP tox results submitted to the TGA in 2011 did not include any dog results. They used rats and monkeys. They first overdosed some rats with iron. There were deaths among animals which had not been overdosed first with iron. Imagine that, no dogs, but it even killed rats. Will Prana get to increase iron levels before dosing? Will they dose high for a long enough period to kill test animals through LT denial of iron? I don't know anything about that process, but it may be interesting to be informed by Prana. Details of the TGA deferiprone submission in 2011 can be seen at  " Australian Public Assessment Report for Deferiprone"                     

"Whileanaemia was observed in treated animals and was associated with increased mortality innon-iron loaded rats, it is unlikely to be due to bone marrow toxicity, as an increase inreticulocyte number accompanied the reduction in red blood cell parameters.Macrocytosis was also seen, suggesting it is also not likely to be due to iron deficiency. Theexact mechanism underlying the observed anaemia is unclear but it should be noted . " 

Seems the dose they used for monkeys was too low to matter much.

Remember the FDA specified dog toxicity testing as I remember it. They already knew the strong effect PBT1(clioquinol) had on dogs from extensive testing done on dogs with CQ several decades ago.