Ferret's Stock to Watch: CYTOPIA LIMITED 07:31, Tuesday, 23 November 2004
BIOTECH RESEARCHER FAST TRACKING ANTI-CANCER DRUG PROGRAM
Sydney - Tuesday - November 23: (RWE Australian Business News) ********************************
OVERVIEW ********
Shareholders of biotech Cytopia heard of some interesting company developments at yesterday's annual meeting.
The good news is that the company will co-develop its drug with Cancer Research UK in a bid to fast track its anti-cancer drug program.
Its novel anti-cancer drug, CYT997, had been accepted by Cancer Research UK into its clinical trial program.
This will give Cytopia direct access to leading British oncologists and world-class clinical trial facilities.
Cancer Research UK is a non-profit cancer research organisation specialising in the rapid advancement of promising anti-cancer agents.
It has taken over 100 new drugs into man for the first time.
CYT997 is a novel microtubule-targeting agent specifically developed by Cytopia research scientists to be orally active.
In animal models of cancer, orally administered CYT997 significantly inhibited tumour growth without adverse effects.
In another report to the Australian Stock Exchange yesterday Cytopia managing director Dr Kevin Healey said, "We are building a pipeline of drug candidates across therapeutic areas such as cancer, immune diseases and cardiovascular disorders, and this year have made great progress with our cancer drug candidate, CYT997, as well as with several kinase inhibitors.
"The company has never been in a stronger position, both with respect to the status of its technology and its cash reserves.
"CYT997 is set to be tested in cancer patients in the first quarter of calendar 2005 and our JAK3 kinase program has attracted worldwide attention from pharmaceutical companies," he said.
"We are confident of the timeline for the clinical development of CYT997 and believe that our JAK3 program is world-competitive and attractive to pharma companies.
"In the coming year we also expect to add JAK2 to our pipeline of drug candidates and possibly one or more other kinase inhibitors.
"We are well positioned to become a world leader in kinase-inhibitor drug development," Dr Healey said.
SHARE PRICE MOVEMENTS *********************
Shares of Cytopia yesterday rose 6c to 68c. Rolling high for the year has been 77.88c and low 45.43c.
Cytopia has implemented a broad discovery program targeting immune disease and cancer.
The company's objective is to develop new, small molecule drugs that can disrupt aberrant cellular control mechanisms in these diseases, at the level of cell surface receptors, as well as their intracellular signalling mechanisms.
Its major focus is on the protein tyrosine kinase family of enzymes (PTKs) many of which play pivotal roles in cell signalling. Kinases are now well-validated drug discovery targets, with the launch of Glivec (also known as Gleevec or imatinib) by Novartis in 2001 to treat chronic myelogenous leukemia.
Cytopia's strategy is to progressively assess all of the molecules in our diverse chemical library for activity against a broad range of kinase targets (a concept known as Parallel Chemical Genetics).
This program generates a matrix of data, leading to a deep understanding of the chemical structures that determine specificity and potency against multiple targets.
In this way, Cytopia is building a pipeline of drug candidates for a broad range of clinical needs.
Cytopia has established a multi-disciplinary, integrated research team which applies rational drug design technologies to accelerate the discovery of drug candidates.
This includes a significant emphasis on the use of in silico technologies to reduce the burden in chemical library production and to increase the probability of identifying specific and potent inhibitors.
BACKGROUND **********
Cytopia is a Melbourne-based drug discovery and development company committed to redefining the way medicines are discovered.
The company is positioned at the cutting-edge of structure-based rational drug design and discovery.
Cytopia's aim is to discover and develop a new generation of therapeutic drugs for cancer and immune diseases.
Already, Cytopia has applied its medicinal chemistry capability, high-throughput screening facility and computational chemistry platform to develop a broad pipeline of novel pre-clinical drug candidates.
Cytopia is focusing its drug development strategy on major areas of unmet clinical need.
Major therapeutic targets are: Cancer, (specifically Prostate Cancer, Lymphoma, Leukemia, and Multiple Myeloma); and Immune Disease, (including Rheumatoid Arthritis and Atopic diseases, such as Eczema and Asthma). Cytopia has built up an impressive portfolio of granted patents and patent applications protecting significant intellectual property real estate, including both proprietary drug discovery targets and new Composition Of Matter patents on novel drug-like enzyme inhibitors.
Fully integrated new laboratory facility is located in the heart of Melbourne, Australia and has links to the Baker Heart Research Institute, the Alfred hospital and Monash University.
Cytopia will maximise shareholder value by discovering, developing and commercialising a pipeline of new chemical entities, aimed at the treatment of certain cancers and immune-related diseases and disorders.
The company's business strategy is to build a judicious mix of in-house late stage clinical development projects with early stage partnering opportunities.
Its overall strategy is to add maximum value to each stream of our activities where we have the resources to do so.
This program generates a matrix of data, leading to an understanding of the chemical structures which determine specificity and potency against multiple targets.
In this way, Cytopia will build a pipeline of drug candidates for a broad range of clinical needs.