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So pivalde, does this new info mean there is a way to check for...

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skint

3,630 Posts.

116

26/12/18

08:47

Post #: 36958023
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Originally posted by pivalde: ↑

I return to this paper because it is IMO a very important paper for PBT434 because it is a 5 y follow-up study in humans measuring mitochondrion function ( glucose consumption by repeated PET scans) and monitoring how brain iron load in human brains relates to this biomarker of mitochondrion function.

So this is a human study and it confirms that the more you have iron in your brain the higher is your risk to get AD. The evidence in this neurodegenerative process is very strong ( small study population but very significant finding in statistical analysis) . Iron is a very clear contributing factor in this neurodegenerative process.

Think about that in some 30% of normal humans this neurodegenerative process has started as early as when we are only 65y old.

We do not have a study how PBT434 will work in these cases, but if trading halt as anything to do with a possible partner, this paper is of big value. Just my opinion !

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So pivalde, does this new info mean there is a way to check for PBT434 target engagement with iron in the brain? Or is it too late.

PBT Price at posting: 2.8¢ Sentiment: None Disclosure: Not Held
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