It’s one of the many reasons why researchers don’t release results as a trickle.
Lets say Drug A is being investigated for efficacy.
And it shows a positive result in 15% of 100 subjects tested.
If the first fifteen patients all responded, then the next eighty-five didn’t, yet they released the results after the first fifteen...you get the idea.
A case-study would be level IV evidence in the UK, compared to an RCT being Ib. The highest level, Ia, being afforded to systemic reviews of multiple RCTs.
Company mis-guidance and funny buggers., page-32
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