my point had been made previously, I am just re-pointing to the concerns
accept pi88 will have similar label warnings, but some key differences
worth a read of the liver phii sae http://www.progen-pharma.com/prs/progen_... not much really related to treatment at 160 mg, can't quite work it out but 2 sae related to treatment at 160mg (?) out of 56, and only 4 all up for 160mg+250mg out of 110, not sure about control
and melanoma sae on 250 mg, 5 out of 44 with at least some not likely related to treatment, not sure about expected with no treatment http://www.progen.com.au/prs/Clinical%20...
Grade 3/4 adverse events were 38% for Nexavar vs. 28% for placebo
see below for not insignificant rates that nexavar patients hair falls out, they get itchy, diarrhea, rash, sick, bleeding, blood pressure
and for 2.5% of them, the old cardiac ischemia/infarction was 2.9% for Nexavar vs. 0.4% for placebo
i think there is a point of difference given similar activity, which would you rather be on
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