NOX 5.00% 10.5¢ noxopharm limited

Well that low content is of course worth a response with some...

  1. 4,947 Posts.
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    Well that low content is of course worth a response with some real content then. Just to lift the quality of the thread out of the gutter.

    Play spot the difference from the two results below. I know it not apples for apples, but it does give some insights....

    2018
    4 SAEs (including 3 deaths) were reported, none were considered related to NOX66. One Adverse Event (Grade 2 anaemia, NOX66 800mg + carbo AUC4) considered possibly related to NOX66 has been reported.
    Column 1 Column 2 Column 3
    1 Completed 6 cycles carbo (AUC4; AUC6) 6 5
    2 Evaluable 2 (1SD; 1PD) 3 (2SD; 1PD)
    3 Ongoing   3
    conclusion NOX66 is well tolerated as a monotherapy and in combination with carboplatin at AUC = 4 or AUC = 6. Efficacy signals from this study warrant further investigation of NOX66 as a chemo-sensitizing agent. Clinical trial information:

    https://meetinglibrary.asco.org/record/158635/abstract

    RESULTS: 2011
    There were no treatment-related deaths
    . There was only one treatment-related hospitalization and 2 grade 4 toxicities. In the cisplatin arm, there were 3 partial responses, 9 patients (56%) achieved stable disease, 4 (25%) progressed, and the overall best response rate was 19%. In the paclitaxel arm, there was one complete response and 2 partial responses, 8 patients (53%) achieved stable disease, 4 patients (27%) progressed, and the overall best response rate was 20%.
    DISCUSSION:

    The combination of IV phenoxodiol with cisplatin or paclitaxel was well tolerated in this study. Cisplatin-phenoxodiol was particularly active and warrants further study in patients with platinum-resistant ovarian cancer.
    https://www.ncbi.nlm.nih.gov/pubmed/21412168?dopt=Abstract.
    Last edited by harvett: 23/05/18
 
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