@SecondopinionThx kind words and do trust I present in a...

@Secondopinion

Thx kind words and do trust I present in a balanced and fairly unbiased manner with supportive evidence to my statements & conclusions. 

In fairness to @playez I can see what they are saying however I don't believe it is as absolute and categorical as they make out. 

Is it stacked against POH now - yes. 

Does it mean dead here & now - no. 

Have they got work cut out - yes. 

I agree as u say, some supporting evidence from playez re their statements would be appreciated however there is nothing that says they have to. 

Is TPGS a direct competitor in the "same" DDS right now - not that I can see and happy to be corrected if so. 

Will TPGS become a direct competitor in the future - possibly if they move into that DDS. 

That is when POH should provide direct comparison studies as TPGS would then be a competitor but not yet. 

Seeing playez has now shifted part of the discussion around supply chain, does TPGS have that advantage & scale - absolutely as it's been around that long in oral DDS so to be expected. 

Does that mean POH couldn't secure production & supply chain if required - no. 

Must first have a product requirement to that level to proceed down that path and obviously POHs focus atm still is product dev and ultimately commercialisation first then supply chain in parallel. 

I still believe TPGS is not developed as yet for transdermal / injectable however if it does become available then yes, existing infrastructure will assist it. 

But does that also mean these producers / suppliers couldn't also assist with TPM? 

Does the mkt say there can be a monopoly of only one transdermal / injectable compound support? 

Even from isochem pdf it clearly states that the DDS discussed is merely being investigated at this time (pg 2).

https://www.google.com.au/url?sa=t&source=web&rct=j&url=https://pmcisochem.fr/sites/default/files/documents/ISOCHEM%2520TPGS%25202015%252008.pdf&ved=2ahUKEwi36Lq1mt_eAhUHr48KHc4-DFoQFjACegQICRAB&usg=AOvVaw0i5szO5YQ_vP7zoOaRps-g&cshid=1542587606594

While here and couldn't see mention of it on a thread search (maybe in an Ann somewhere but not checked?), anyone know of Lambada and how they fit? 

http://www.lambdacanada-cro.com/targeted-penetration-matrix-tpm-innovative-transdermal-delivery-system/

Cheers FMF