Short term effects of cannabinoids like CBD as anti depressants...

Short term effects of cannabinoids like CBD as anti depressants are clear. You can take that to the bank.

CBD directly activates the 5-HT1A (hydroxytryptamine) serotonin receptor, thereby conferring an anti-anxiety effect

What even better is the longer term effects of cannabinoids on the CAUSE for the environment that creates depression, both inside and outside a patient body. For example, lack of sleep will be a co factor both inside the body and outside the body that accentuate depression.