Pixi, I doubt high dosing would be a problem. As I remember it was long term accumulation at 250 that was a problem in dogs only. The average hospital stay for MRSA cases is only about 10 days, just over double non MRSA infections. 250mg dose has been shown to be well tolerated out to 2 years in humans. As I recall the phase1 trials for PBT2 were up to 800mg with no problems in humans.
I doubt the FDA would prevent PBT2/zinc being given, once proven effective in humans, when the patient just has short time to live, once antibiotics no longer work.
There are other potentially effective treatments. From 2015. [ But now researchers have found a way to kill the deadly bacteria using those very antibiotics. The trick is using a combination of three antibiotics at once, which has been successful in test tubes and laboratory mice. Researchers say they are confident the same strategy will work in people."Using the drug combination to treat people has the potential to begin quickly because all three antibiotics are approved by the FDA," says Dantas, the lead author on the study, which was published online in the journal Nature Chemical Biology. The three prescription medications, meropenem, piperacillin and tazobactam, are from a class of antibiotics called beta-lactams that haven’t been effective against MRSA for decades. Like HIV, the MRSA bacterium has mutated frequently and has become immune to even the toughest antibiotics available today.Dantas' team, working with collaborators at Barnes-Jewish Hospital in St. Louis, tested and genetically analyzed 73 different strains of MRSA to represent the range of hospital-acquired and community-acquired forms of the pathogen. Then they treated the MRSA microbes with the three-drug combination. The treatments were one hundred percent effective.Furthermore, experiments conducted by additional collaborators at the University of Notre Dame, have shown that the combination therapy cures MRSA-infected mice."Without treatment, these MRSA-infected mice tend to live less than a day, but the three-drug combination cured the mice," Dantas says. "After the treatment, the mice were thriving."Although the drugs, which work by attacking the cell wall of the bacteria, have been ineffective alone, together they are capable of knocking down that wall. In the studies so far, the three-drug combination hasn’t produced further drug-resistance in MRSA."This three-drug combination appears to prevent MRSA from becoming resistant to it," Dantas explains. "We know all bacteria eventually develop resistance to antibiotics, but this trio buys us some time, potentially a significant amount of time." https://www.hivplusmag.com/treatment/2015/09/18/cure-mrsa-three-antibiotics-together-kill-drug-resistant-staph-infection
PBT Price at posting:
3.7¢ Sentiment: None Disclosure: Not Held
