Ann: Clinical Trial Publication Provisionally Accepted, page-42

First 42 Last

Share
Profile

Follow
havana19

424 Posts.

30

26/06/18

19:30

Post #: 33964020
Share

Originally posted by Southoz ↑

I think the abstract tells you all you need to know.

The study is to be published in a Frontiers journal. The acceptance rate of papers in these journals is around 90% (when you pay the hefty author fee). Well conducted studies with statistically significant results that are important are never published there.

The drop-out rate of 60% in the study tells you that on an intent to treat (ITT) basis the trial would have failed. It is the ITT analysis that gets you the FDA labelling claim that NTI are seeking. Not the analysis of only those who completed.

The degree of difference between baseline and completion in the active arm is not the difference that is important at all. This simply reflects a regression to the mean effect. The fact that there may have been more regression to the mean in the active compared to the placebo simply reflects baseline differences.

In a small study like this the important difference is the difference between active and placebo at follow-up controlling for baseline.

The neuroscience blogger sphere is going to have great fun with this paper when it comes out.

Expand

@Southoz I can't stop thinking about this post. You sound like you really know your stuff on FDA and scientific lingo and so it really worries me. Ive looked into frontiers credibility and basically what you said is what others online said about their rep. But are you saying this product is doomed? its my opinion that we definitely need fda approval and that is the next milestone I am waiting on after successful publication. So if theres no way we can get fda approval then I might as well sell after results are published. ???

NTI Price at posting: 18.0¢ Sentiment: Buy Disclosure: Held
2 Upvote

0 Great analysis

Reply

There are more pages in this discussion • 7 more messages in this thread...

First 42 Last

Add NTI (ASX) to my watchlist

(20min delay)
Last 6.9¢		Change 0.002(2.99%)		Mkt cap ! $64.55M

Open	High	Low	Value	Volume
6.7¢	7.2¢	6.7¢	$45.29K	648.2K

Buyers (Bids)

No.	Vol.	Price($)
3	684701	6.6¢

Sellers (Offers)

Price($)	Vol.	No.
6.9¢	100000	1

View Market Depth

No.	Vol.	Price($)
4	589299	0.070
1	36231	0.069
5	240000	0.068
2	255000	0.067
3	262000	0.066

Price($)	Vol.	No.
0.072	100000	1
0.074	40000	1
0.075	738582	2
0.076	90000	1
0.077	190000	3

Last trade - 15.37pm 22/11/2024 (20 minute delay)

NTI (ASX) Chart