RHY 0.00% 10.0¢ rhythm biosciences limited

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    Hey everyone hope someone with a little more insight can help me here.

    I'm wondering why the stage 5 trial didn't work out. The prospectus seems to blame one of the biomarkers not performing as expected.

    I can see there's a lot of collaboration with CSIRO to develop the final biomarker / antibodies and confirm that they can be sustainably produced (supply chain control).

    Again from the prospectus and a recent announcement I can see that stage 6 will apply the new biomarker / antibodies to the samples from stage 5 trial to confirm success. At the same time stage 7 (1000 person trial) will begin to be organised concurrently to save time.

    Does someone have a handle on, or has spoken to the company about why stage 5 trial didn't work out specifically and why they are confident that the new biomarker developed by CSIRO will succeed when applied to stage 5 samples?

    Obviously they're trying to keep the timeline going though if the new biomarker from CSIRO doesn't work as expected when they apply it to the stage 5 samples to confirm success, then timelines will be pushed out quite a lot as the stage 7 trial will need to be pushed back.

    Any thoughts would be welcome. I've read the research note shared in the thread though I don't believe it addressed this series of questions.

    Cheers

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